Advanced Biomart has developed a unique and comprehensive protein crystallization platform that enables high-resolution structure determination through X-ray crystallography, addressing the bottleneck in drug target structure determination. X-ray crystallography is one of the most powerful techniques for determining protein structures and is a commonly used structural biology technique for determining the three-dimensional structures of proteins and other biomolecules.
With years of experience, Advanced Biomart provides a range of services from gene to crystal structure, including structure design, protein expression and purification, high-throughput screening of crystallization conditions, compound or fragment soaking, and structure determination.
Protein Crystallization Service includes:
►Crystallization condition screen
►X-ray diffraction data collection
►Co-crystallization of Protein-compound; Fragment screen by soaking or co-crystallization
►Determination of structure
Key Features of Protein Crystallization Service:
♦ High Quality
♦ Experienced Scientists
♦ Instruments: Refrigerated centrifuge，Crystallization screening instrument，X-ray diffractometer，X-ray generator，Goniometer
♦ Cost Effective
♦ Fast & Reliable
|1||Crystallization condition screen by Mosquito||3-9 weeks||Commercial screen kits, Sparse matrix screen, 18 ℃ and 4 ℃|
|2||X-ray diffraction data collection at Synchrone||3-9 weeks||Collected at SSRF weekly|
A. Co-crystallization of Protein-compound
B. Fragment Screen by soaking or co-crystallization
|3-9 weeks||Binding affinity date of compounds with protein is crucial|
|4||Determination of structure||TBD||Phase solved by MR, SeMet or MIR|
Contact us now for more information about our protein crystallization services, we will send you a quotation within 24h.